Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

System Xc /GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

FSP1: a key regulator of ferroptosis

W Li, L Liang, S Liu, H Yi, Y Zhou - Trends in Molecular Medicine, 2023 - cell.com
Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Ferroptosis nanomedicine: clinical challenges and opportunities for modulating tumor metabolic and immunological landscape

H Yang, X Yao, Y Liu, X Shen, M Li, Z Luo - Acs Nano, 2023 - ACS Publications
Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Oxygen self-generating nanoreactor mediated ferroptosis activation and immunotherapy in triple-negative breast cancer

K Li, K Xu, Y He, Y Yang, M Tan, Y Mao, Y Zou… - ACS …, 2023 - ACS Publications
The hypoxia microenvironment of solid tumors poses a technological bottleneck for
ferroptosis and immunotherapy in clinical oncology. Nanoreactors based on special …

Bifunctional cascading nanozymes based on carbon dots promotes photodynamic therapy by regulating hypoxia and glycolysis

T Luo, H Yang, R Wang, Y Pu, Z Cai, Y Zhao, Q Bi… - ACS …, 2023 - ACS Publications
Photodynamic therapy (PDT) still faces great challenges with suitable photosensitizers,
oxygen supply, and reactive oxygen species (ROS) accumulation, especially in the tumor …

Distinct features of iron based metal organic frameworks (MOFs) for ferroptosis mediated cancer therapy: A comprehensive review

R Kudarha, N Dhas, S Mutalik - Coordination Chemistry Reviews, 2023 - Elsevier
In the recent years, ferroptosis, a novel non-apoptotic iron dependent form of programmed
cell death, gained lots of attention in the treatment of several disease like cancer, ischemic …

A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity

Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …

Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Y Wang, X Jia, S An, W Yin, J Huang… - Advanced …, 2024 - Wiley Online Library
Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

All-in-one engineering multifunctional nanoplatforms for sensitizing tumor low-temperature photothermal therapy in vivo

K Li, K Xu, S Liu, Y He, M Tan, Y Mao, Y Yang, J Wu… - ACS …, 2023 - ACS Publications
Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the
photothermal effect at low temperatures to selectively eliminate tumor cells, while …