The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …

This review highlights the biological importance of mitochondrial energy metabolism and the
applications of multiple optical/electrochemical approaches to determine energy …

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

The emergence of small open reading frame (sORF)-encoded peptides (SEPs) is rapidly
expanding the known proteome at the lower end of the size distribution. Here, we show that …

Complex I (CI) is the largest protein complex in the mitochondrial oxidative phosphorylation
electron transport chain of the inner mitochondrial membrane and plays a key role in the …

Contrary to their well-known functions in nutrient breakdown, mitochondria are also
important biosynthetic hubs and express an evolutionarily conserved mitochondrial fatty acid …

Mitochondria control life and death in eukaryotic cells. Harboring a unique circular genome,
a by‐product of an ancient endosymbiotic event, mitochondria maintains a specialized and …

Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty
acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is …

Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its
biogenesis requires the assembly and integration of distinct intermediate modules, mediated …

Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory function. MtFAS
generates the octanoic acid precursor for lipoic acid synthesis, but the role of longer fatty …