Overview of the genetics of alcohol use disorder

EA Tawa, SD Hall, FW Lohoff - Alcohol and alcoholism, 2016 - academic.oup.com
Abstract Aims Alcohol Use Disorder (AUD) is a chronic psychiatric illness characterized by
harmful drinking patterns leading to negative emotional, physical, and social ramifications …

Alcohol dependence genetics: lessons learned from genome‐wide association studies (GWAS) and post‐GWAS analyses

AB Hart, HR Kranzler - Alcoholism: Clinical and Experimental …, 2015 - Wiley Online Library
Background Alcohol dependence (AD) is a complex psychiatric disorder and a significant
public health problem. Twin and family‐based studies have consistently estimated its …

Genome-wide association study of alcohol dependence: significant findings in African-and European-Americans including novel risk loci

J Gelernter, HR Kranzler, R Sherva, L Almasy… - Molecular …, 2014 - nature.com
We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-
American (AA) populations, with replication in independent samples of EAs, AAs and …

Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene

J Gelernter, R Sherva, R Koesterer, L Almasy… - Molecular …, 2014 - nature.com
We report a genome-wide association study (GWAS) for cocaine dependence (CD) in three
sets of African-and European-American subjects (AAs and EAs, respectively) to identify …

The Collaborative Study on the Genetics of Alcoholism: Overview

A Agrawal, SJ Brislin, KK Bucholz… - Genes, Brain and …, 2023 - Wiley Online Library
Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders
with etiological origins in the brain and the environment. To outline the causes and …

Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count and individual criteria

D Lai, L Wetherill, S Bertelsen, CE Carey… - Genes, Brain and …, 2019 - Wiley Online Library
Genome‐wide association studies (GWAS) of alcohol dependence (AD) have reliably
identified variation within alcohol metabolizing genes (eg, ADH1B) but have inconsistently …

Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults

JE Salvatore, F Aliev, K Bucholz… - Clinical …, 2015 - journals.sagepub.com
In this project, we aimed to bring large-scale gene-identification findings into a
developmental psychopathology framework. Using a family-based sample, we tested …

An inside job: how endosomal Na+/H+ exchangers link to autism and neurological disease

KC Kondapalli, H Prasad, R Rao - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Autism imposes a major impediment to childhood development and a huge emotional and
financial burden on society. In recent years, there has been rapidly accumulating genetic …

Stress–response pathways are altered in the hippocampus of chronic alcoholics

JN McClintick, X Xuei, JA Tischfield, A Goate, T Foroud… - Alcohol, 2013 - Elsevier
The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on
the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial …

ALDH2 is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sample

EE Quillen, XD Chen, L Almasy, F Yang… - American Journal of …, 2014 - Wiley Online Library
Alcohol dependence (AD) is a moderately heritable phenotype with a small number of
known risk genes mapped via linkage or candidate gene studies. We considered 313 males …