Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG
repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …

We have previously shown that exon 1 of the huntingtin gene does not always splice to exon
2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the …

Normal brain function depends on the interaction between highly specialized neurons that
operate within anatomically and functionally distinct brain regions. Neuronal specification is …

Astrocytes tile the central nervous system and are widely implicated in brain diseases, but
the molecular mechanisms by which astrocytes contribute to brain disorders remain …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …