Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the
concentrations of target ligands and regulate gene expression accordingly. In the past 20 …

SUMMARY A critical feature of the hypothesized RNA world would have been the ability to
control chemical processes in response to environmental cues. Riboswitches present …

Fluorogenic RNA aptamers are used to genetically encode fluorescent RNA and to construct
RNA-based metabolite sensors. Unlike naturally occurring aptamers that efficiently fold and …

Magnesium ions have an important role in the structure and folding mechanism of
ribonucleic acid systems. To properly simulate these biophysical processes, the applied …

The cellular concentrations of certain metabolites are assiduously monitored to achieve
appropriate levels of gene expression. Although proteins have long been known to act as …

Background Riboswitches are noncoding RNA structures that appropriately regulate genes
in response to changing cellular conditions. The expression of many proteins involved in …

A wealth of information on RNA folding and ribonucleoprotein assembly has emerged from
analyses of structures and from the use of innovative biophysical tools. Although integrating …

Riboswitches regulate genes through structural changes in ligand-binding RNA aptamers.
With the use of an optical-trapping assay based on in situ transcription by a molecule of RNA …

Many recently discovered RNA functions rely on highly complex multistep conformational
transitions that occur in response to an array of cellular signals. These dynamics accompany …

The use of fluorescent nucleic acid base analogues is becoming increasingly important in
the fields of biology, biochemistry and biophysical chemistry as well as in the field of DNA …