Suramin was the first urea-based drug to be approved in clinic, and in the following century
a number of milestone drugs based on this scaffold were developed. Indeed, urea soon …

Alzheimer's is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …

In an attempt to design and prepare a new library of anticancer candidates, focused
thiopropargylated benzothiazole was reacted with ethyl azidoacetate and/or ethyl …

Purpose Glioblastoma (GBM) is the most prevalent, malignant, primary brain tumor in adults,
characterized by limited treatment options, frequent relapse, and short survival after …

New molecular crystals, namely acetamidinium picrate (AP), and acetamidinium p-toluene
sulphonate (APTS) have been synthesised and grown as single crystals. Crystal structure of …

(adamantane-1-carbonyl-3-(1-naphthyl)) thiourea (C 22 H 24 N 2 OS (4), was synthesized
by the reaction of freshly prepared adamantane-1-carbonyl chloride from corresponding …

The carbazole skeleton, a key structural motif occurring naturally or chemically synthesized,
showed various biological activities. Molecular hybridization based on the combination of …

A Fe (OTf) 3-and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is
demonstrated. This biomimetic-catalyst-oriented sustainable and green method could …

The dysregulation of RNA binding proteins (RBPs) regulates the progression of several
cancers. However, information on the overall functions of RBPs in prostate cancer (PCa) …

The first direct and selective 3, 6-di-alkylation of carbazoles via iron-catalyzed hydroarylation
of styrenes is demonstrated. This simple, general and efficient method could deliver a wide …