The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia
Abstract Purpose: KPT-8602 (Eltanexor) is a second-generation exportin-1 (XPO1) inhibitor
with potent activity against acute lymphoblastic leukemia (ALL) in preclinical models and …
with potent activity against acute lymphoblastic leukemia (ALL) in preclinical models and …
[HTML][HTML] XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB
B Galinski, M Luxemburg, Y Landesman, B Pawel… - Translational …, 2021 - Elsevier
Across many cancer types in adults, upregulation of the nuclear-to-cytoplasmic transport
protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an …
protein Exportin-1 (XPO1) correlates with poor outcome and responsiveness to selinexor, an …
[HTML][HTML] Neurotensin Receptor
ABSTRACT SALL2 is a transcription factor involved in development and disease.
Deregulation of SALL2 has been associated with cancer, suggesting that it plays a role in …
Deregulation of SALL2 has been associated with cancer, suggesting that it plays a role in …
[图书][B] XPO1 Overexpression and Drug Targeting in a Combination Strategy for High-Risk Neuroblastoma
B Galinski - 2021 - search.proquest.com
Neuroblastoma is a pediatric developmental cancer of the peripheral nervous system. The
cells of origin for this cancer are the neural crest cells, which give rise to the peripheral …
cells of origin for this cancer are the neural crest cells, which give rise to the peripheral …
[PDF][PDF] COMBINING TARGETED THERAPY AND CHEMOTHERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIA
D VERBEKE - 2020 - lirias.kuleuven.be
Acute lymphoblastic leukemia (ALL) is a hematological disease, which arises from the
malignant T or B cell transformation of developing progenitor cells. It is the most common …
malignant T or B cell transformation of developing progenitor cells. It is the most common …