Symptomatic hip osteonecrosis is a disabling condition with a poorly understood aetiology
and pathogenesis. Numerous treatment options for hip osteonecrosis are described, which …

The purpose of this study was to compare the outcomes of cementless primary total hip
arthroplasty (THA) in sickle cell patients compared to the remaining cohort of osteonecrosis …

Phthalimide derivatives containing furoxanyl subunits as nitric oxide (NO)-donors (3a–g)
were designed, synthesized, and evaluated in vitro and in vivo for their potential uses in the …

A novel series of thalidomide derivatives (4a–f) designed by molecular hybridization were
synthesized and evaluated in vitro and in vivo for their potential use in the oral treatment of …

Sickle Cell Disease (SCD) is one of the most prevalent hematological diseases in the world.
SCD is a genetic disease characterized by punctual mutation that basis on the exchange of …

Resumo Sickle Cell Disease (SCD) is a disease characterized by a punctual mutation (GTG-
GAG) in the sixth codon of the gamma globin gene leading to a substitution of glutamic acid …

Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the
symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide–nitric oxide …

Abstract N-oxide derivatives 5 (a–b), 8 (a–b), and 11 (a–c) were designed, synthesized and
evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell …

Abstract Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological
diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable …

Editorial de Melo, Chin & dos Santos approved by the US FDA to treat SCD. In vivo, HU is
metabolized to NO, which induces the expression of the γ-globin gene (HbG1 and HbG2) …