Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Epithelial Na+ channels (ENaCs) are members of a family of cation channels that function as
sensors of the extracellular environment. ENaCs are activated by specific proteases in the …

Proteases are fundamental for a plethora of biological processes, including signalling and
tissue remodelling, and dysregulated proteolytic activity can result in pathogenesis. In this …

Objective: To frame revised guidelines on diagnosis, evaluation, management, and
supportive care of patients with the illness. Process: The guidelines combine evidence …

Epithelial Na+ channels (ENaCs) are members of the ENaC/degenerin family of ion
channels that evolved to respond to extracellular factors. In addition to being expressed in …

The regulation of body fluid balance is a key concern in health and disease and comprises
three concepts. The first concept pertains to the relationship between total body water (TBW) …

Physical, chemical, and social environments adversely affect the molecular process and
results in cell signal transduction and the subsequent transcription factor dysregulation …

Arterial hypertension (HTN) is commonly encountered by clinicians treating children with
steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS). Although the …

Sodium retention and extracellular volume expansion are typical features of patients with
nephrotic syndrome. In recent years, from in vitro data, endoluminal activation of the …

Aim In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active
plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to …