The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the
human population. Different etiological factors such as hepatitis B and C virus, alcohol and …

Therapeutic attempts to treat hepatocellular carcinoma (HCC) frequently result in a poor
response or treatment failure. The efficacy of approved drugs and survival expectancies is …

Background Many molecular alterations are shared by embryonic liver development and
hepatocellular carcinoma (HCC). Identifying the common molecular events would provide a …

Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …

Background Tumor metastasis is one of the leading causes of poor prognosis for colorectal
cancer (CRC) patients. Loss of Smad4 contributes to aggression process in many human …

Liver cancer represents a substantial global health challenge, contributing significantly to
worldwide morbidity and mortality. It has long been understood that tumors are not …

Aberrant activation of the TGF-β/SMAD signaling pathway is often observed in
hepatocellular carcinoma (HCC). Whether lncRNA regulates the TGF-β/SMAD signaling …

The bone morphogenetic proteins (BMPs) play fundamental roles in embryonic
development and control differentiation of a diverse set of cell types. It is therefore of no …

Hepatic stellate cell (HSC), initially analyzed by von Kupffer, in 1876, revealed to be an
extraordinary mesenchymal cell, essential for both hepatocellular function and lesions …