Bile acid, the final product of cholesterol breakdown, functions as a complex regulator and
signaling factor in human metabolism. Chronic metabolic diseases pose significant medical …

Background High ultra-processed food consumption is associated with higher risk of CKD.
However, there is no biomarker for ultra-processed food, and the mechanism through which …

Background Metabolomics has the potential to enhance dietary assessment by revealing
objective measures of many aspects of human food intake. Although metabolomics studies …

Coffee is a beverage consumed globally. Although few studies have indicated adverse
effects, it is typically a beneficial health-promoting agent in a range of diseases, including …

Background Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and
variable response to therapy. The metabolome has been implicated in the pathogenesis of …

Rationale and objective A causal relationship concerning coffee intake and diabetic
nephropathy (DN) is controversial. We conducted a Mendelian randomization study to …

The relationship between coffee consumption and diabetes-related vascular complications
remains unclear. To eliminate confounding by smoking, this study assessed the …

Background & aims Population-based studies have suggested a protective effect of coffee
against development of chronic kidney disease (CKD), possibly through coffee's anti …

This review provides a comprehensive synthesis of longitudinal observational and
interventional studies on the cardiometabolic effects of coffee consumption. It explores …

BACKGROUND: Metabolomics may reveal novel biomarkers for coronary heart disease
(CHD). We aimed to identify circulating metabolites and construct a metabolite risk score …