Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury,
which results in increased pulmonary vascular permeability and loss of aerated lung tissue …

Soon after its discovery in the 18th century, oxygen was applied as a therapeutic agent to
treat severely ill patients. Lack of oxygen, commonly termed as hypoxia, is frequently …

Background Neurodevelopmental disabilities persist in survivors of neonatal hypoxic-
ischemic encephalopathy (HIE) despite treatment with therapeutic hypothermia …

BACKGROUND: Intermittent hypoxia may occur in a number of clinical scenarios, including
interruption of myocardial blood flow or breathing disorders such as obstructive sleep …

The pulmonary endothelium is an immediate recipient of high oxygen concentrations upon
oxygen therapy and mediates down‐stream responses. Cyclic collapse and reopening of …

Arterial oxygen partial pressure can increase during inspiration and decrease during
expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it …

Management of ARDS in patients with acute brain injury (ABI) differs in several ways from
non-neurological subjects. Ventilation must be doubly protective, for the lung and the brain …

Gas partial pressures within the cell microenvironment are one of the key modulators of cell
pathophysiology. Indeed, respiratory gases (O2 and CO2) are usually altered in respiratory …

BACKGROUND Perioperative oxygen (O 2) therapy can cause hyperoxia. Extreme
hyperoxia can injure the cardiovascular system and remote organs. OBJECTIVE Our primary …

Background There is considerable interest in oxygen partial pressure (P o2) monitoring in
physiology, and in tracking P o2 changes dynamically when it varies rapidly. For example …