[HTML][HTML] Recent advances in understanding acute respiratory distress syndrome

P Wohlrab, F Kraft, V Tretter, R Ullrich… - …, 2018 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury,
which results in increased pulmonary vascular permeability and loss of aerated lung tissue …

[HTML][HTML] Investigating disturbances of oxygen homeostasis: from cellular mechanisms to the clinical practice

V Tretter, ML Zach, S Böhme, R Ullrich… - Frontiers in …, 2020 - frontiersin.org
Soon after its discovery in the 18th century, oxygen was applied as a therapeutic agent to
treat severely ill patients. Lack of oxygen, commonly termed as hypoxia, is frequently …

[HTML][HTML] A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received …

VJ Burton, G Gerner, E Cristofalo, S Chung… - BMC neurology, 2015 - Springer
Background Neurodevelopmental disabilities persist in survivors of neonatal hypoxic-
ischemic encephalopathy (HIE) despite treatment with therapeutic hypothermia …

Intermittent hypoxia causes inflammation and injury to human adult cardiac myocytes

J Wu, J Stefaniak, C Hafner, JP Schramel… - Anesthesia & …, 2016 - journals.lww.com
BACKGROUND: Intermittent hypoxia may occur in a number of clinical scenarios, including
interruption of myocardial blood flow or breathing disorders such as obstructive sleep …

Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions

P Wohlrab, M Johann Danhofer… - Physiological …, 2021 - Wiley Online Library
The pulmonary endothelium is an immediate recipient of high oxygen concentrations upon
oxygen therapy and mediates down‐stream responses. Cyclic collapse and reopening of …

[HTML][HTML] Respiratory oscillations in alveolar oxygen tension measured in arterial blood

F Formenti, N Bommakanti, R Chen, JN Cronin… - Scientific reports, 2017 - nature.com
Arterial oxygen partial pressure can increase during inspiration and decrease during
expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it …

[HTML][HTML] ARDS in the brain-injured patient: what's different?

M Oddo, G Citerio - Intensive care medicine, 2016 - Springer
Management of ARDS in patients with acute brain injury (ABI) differs in several ways from
non-neurological subjects. Ventilation must be doubly protective, for the lung and the brain …

[HTML][HTML] Gas partial pressure in cultured cells: patho-physiological importance and methodological approaches

R Farré, I Almendros, JM Montserrat, D Gozal… - Frontiers in …, 2018 - frontiersin.org
Gas partial pressures within the cell microenvironment are one of the key modulators of cell
pathophysiology. Indeed, respiratory gases (O2 and CO2) are usually altered in respiratory …

Moderate hyperoxia induces inflammation, apoptosis and necrosis in human umbilical vein endothelial cells: an in-vitro study

C Hafner, J Wu, L Soto-Gonzalez, C Kaun… - European Journal of …, 2017 - journals.lww.com
BACKGROUND Perioperative oxygen (O 2) therapy can cause hyperoxia. Extreme
hyperoxia can injure the cardiovascular system and remote organs. OBJECTIVE Our primary …

Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome

F Formenti, R Chen, H McPeak… - British Journal of …, 2015 - academic.oup.com
Background There is considerable interest in oxygen partial pressure (P o2) monitoring in
physiology, and in tracking P o2 changes dynamically when it varies rapidly. For example …