Cocrystal engineering of pharmaceutical solids: Therapeutic potential and challenges
Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …
molecules in the same crystal lattice that are physically connected by non-ionic and non …
Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …
cancer deaths throughout the world. The shortfall of affordable and effective first-line …
[HTML][HTML] Exploring the therapeutic potential of mitochondrial uncouplers in cancer
R Shrestha, E Johnson, FL Byrne - Molecular metabolism, 2021 - Elsevier
Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …
Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection …
H Hao, Y Zhang, X Hu, W Guo, C Yang… - European Journal of …, 2023 - Elsevier
Gallic acid (GA) is a naturally occurring polyphenolic compound exhibiting anti-tumor
activity. To clarify the capability of GA in optimizing the in vitro/in vivo properties of the first …
activity. To clarify the capability of GA in optimizing the in vitro/in vivo properties of the first …
Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters
In this work, we have developed and tested a dry powder form of niclosamide made by thin-
film freezing (TFF) and administered it by inhalation to rats and hamsters to gather data …
film freezing (TFF) and administered it by inhalation to rats and hamsters to gather data …
[HTML][HTML] Solid-state and particle size control of pharmaceutical cocrystals using atomization-based techniques
Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …
development of new API molecules and can influence the impact of new medicines or halt …
Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications
Cancer ranks as the second foremost cause of death in various corners of the globe. The
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …
Amorphous solid dispersions and the contribution of nanoparticles to in vitro dissolution and in vivo testing: Niclosamide as a case study
We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …
niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this …
Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation
The rise of tuberculosis (TB) superbugs has impeded efforts to control this infectious ailment,
and new treatment options are few. Paradoxical Inflammation (PI) is another major problem …
and new treatment options are few. Paradoxical Inflammation (PI) is another major problem …
Nanocarrier mediated autophagy: an emerging trend for cancer therapy
Autophagy is defined as a process in which cell undergo sequential sequestration of
degraded protein and damaged organelles for maintenance of cellular hemostasis …
degraded protein and damaged organelles for maintenance of cellular hemostasis …