The m6A epitranscriptome: transcriptome plasticity in brain development and function

I Livneh, S Moshitch-Moshkovitz, N Amariglio… - Nature Reviews …, 2020 - nature.com
The field of epitranscriptomics examines the recently deciphered form of gene expression
regulation that is mediated by type-and site-specific RNA modifications. Similarly to the role …

[HTML][HTML] The role of m6A modification in physiology and disease

C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong… - Cell death & …, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …

[HTML][HTML] Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

P Bawankar, T Lence, C Paolantoni… - Nature …, 2021 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant internal modification on mRNA
which influences most steps of mRNA metabolism and is involved in several biological …

[HTML][HTML] Deciphering epitranscriptome: modification of mRNA bases provides a new perspective for post-transcriptional regulation of gene expression

S Kumar, T Mohapatra - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Gene regulation depends on dynamic and reversibly modifiable biological and chemical
information in the epigenome/epitranscriptome. Accumulating evidence suggests that …

[HTML][HTML] Landscape and regulation of m6A and m6Am methylome across human and mouse tissues

K Li, J Cai, M Zhang, X Zhang, X Xiong, H Meng, X Xu… - Molecular cell, 2020 - cell.com
Summary N 6-methyladenosine (m 6 A), the most abundant internal mRNA modification, and
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …

[HTML][HTML] Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

AE Arguello, A Li, X Sun, TW Eggert, E Mairhofer… - Nature …, 2022 - nature.com
Epitranscriptomic RNA modifications can regulate fundamental biological processes, but we
lack approaches to map modification sites and probe writer enzymes. Here we present a …

[HTML][HTML] RNA 2′-O-methylation (Nm) modification in human diseases

DG Dimitrova, L Teysset, C Carré - Genes, 2019 - mdpi.com
Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

L Worpenberg, C Paolantoni, S Longhi… - The EMBO …, 2021 - embopress.org
Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous …

[HTML][HTML] The role of mRNA m6A methylation in the nervous system

J Li, X Yang, Z Qi, Y Sang, Y Liu, B Xu, W Liu, Z Xu… - Cell & bioscience, 2019 - Springer
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …

N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons

Y Li, X Guo, L Sun, J Xiao, S Su, S Du, Z Li… - Advanced …, 2020 - Wiley Online Library
Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root
ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) …