Cellular cytotoxicity, the ability to kill other cells, is an important effector mechanism of the
immune system to combat viral infections and cancer. Cytotoxic T cells and natural killer …

As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Adaptive immune responses are defined as antigen sensitization–dependent and antigen-
specific responses leading to establishment of long-lived immunological memory. Although …

Human NK cells are innate immune effectors that play a critical roles in the control of viral
infection and malignancy. The importance of their homeostasis and function can be …

Natural Killer (NK) cells can engage multiple virally infected or tumor cells sequentially and
deliver perforin for cytolytic killing of these targets. Using microscopy to visualize …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …

Natural killer (NK) cells are innate immune effectors that lyse virally infected and tumorigenic
cells through the formation of an immunological synapse. Actin remodeling at the lytic …

NK cells are cytotoxic lymphocytes important in defense against viral infection and cancer.
NK cells mediate cytotoxicity predominantly through directed secretion of lytic granules …