New findings obtained during the past years, especially the discovery of mutations in the
genes associated with brain iron metabolism, have provided key insights into the …

Neurodegenerative disorders include a variety of pathological conditions, which share
similar critical metabolic processes such as protein aggregation and oxidative stress, both of …

Abnormal iron homeostasis is increasingly thought to contribute to the pathogenesis of
several neurodegenerative disorders. We have previously reported impaired iron …

Safe trafficking of iron across the cell membrane is a delicate process that requires specific
protein carriers. While many proteins involved in iron uptake by cells are known, only one …

The transcellular trafficking of iron from the blood into the brain interstitium depends on iron
uptake proteins in the apical membrane of brain microvascular capillary endothelial cells …

In the last 20 years, several new genes and proteins involved in iron metabolism in
eukaryotes, particularly related to pathological states both in animal models and in humans …

Iron balance is tightly linked to inflammation and it has been demonstrated that many
proteins involved in cellular iron management are up-or down-regulated by inflammatory …

We investigated the cytosolic proteome of inflamed synovial tissue by hierarchical clustering
analysis and validated the feasibility of this proteome analysis by identifying proteins that …

Background Iron is necessary for neuronal function but in excess generates
neurodegeneration. Although most of the components of the iron homeostasis machinery …

Previously, we demonstrated that IL-1β was able to increase iron efflux from glial cells
through a coordinate induction of both ferroportin-1 (Fpn) and ceruloplasmin (Cp) synthesis …