Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …

Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …

FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal
organ precursors. Using a human stem cell model of pancreas differentiation, we here …

FOXA1, a transcription factor involved in epigenetic reprogramming, is crucial for breast
cancer progression. However, the mechanisms by which FOXA1 achieves its oncogenic …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

Cancer is a leading cause of death worldwide, resulting in∼ 10 million deaths in 2020.
Major oncogenic effectors are the Myc proto-oncogene family, which consists of three …

FOXA family proteins act as pioneer factors by remodeling compact chromatin structures.
FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal …