Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative
stress has been identified as a key factor in impaired diabetic wound healing …

Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …

The prevalence of diabetes is continuously increasing in the recent decades. Persistent
hyperglycemia, hyperinsulinemia and the subsequent oxidative stress result in diabetic …

Background/Aims: Diabetic non-healing skin ulcers represent a serious challenge in clinical
practice, in which the hyperglycemia-induced disturbance of angiogenesis, and endothelial …

Mitochondrial injury in granulosa cells is associated with the pathogenesis of polycystic
ovary syndrome (PCOS). However, the protective effects of melatonin against mitochondrial …

The increasing lifespan in developed countries results in age-associated chronic diseases.
Biological aging is a complex process associated with accumulated cellular damage by …