The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Resting-state fMRI was first described by Biswal et al in 1995 and has since then been
widely used in both healthy subjects and patients with various neurologic, neurosurgical …

Timing is critical to most forms of learning, behavior, and sensory-motor processing.
Converging evidence supports the notion that, precisely because of its importance across a …

Traditionally studies of brain function have focused on task-evoked responses. By their very
nature such experiments tacitly encourage a reflexive view of brain function. While such an …

Little is known about the brain-wide correlation of electrophysiological signals. We found
that spontaneous oscillatory neuronal activity exhibited frequency-specific spatial correlation …

Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

The premise of the standard regulatory model,“homeostasis”, is flawed: the goal of
regulation is not to preserve constancy of the internal milieu. Rather, it is to continually adjust …

Brain hemodynamics serve as a proxy for neural activity in a range of noninvasive
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …

Inter-individual variability in perception, thought and action is frequently treated as a source
of'noise'in scientific investigations of the neural mechanisms that underlie these processes …