Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

Diagnosis of neonatal sepsis: the role of inflammatory markers

J Eichberger, E Resch, B Resch - Frontiers in Pediatrics, 2022 - frontiersin.org
This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …

Early-onset neonatal sepsis

KA Simonsen, AL Anderson-Berry… - Clinical microbiology …, 2014 - Am Soc Microbiol
Early-onset sepsis remains a common and serious problem for neonates, especially preterm
infants. Group B streptococcus (GBS) is the most common etiologic agent, while Escherichia …

Diagnostics for neonatal sepsis: current approaches and future directions

PY Iroh Tam, CM Bendel - Pediatric research, 2017 - nature.com
Progress has been made in the reduction of morbidity and mortality from neonatal sepsis.
However, diagnosis continues to rely primarily on conventional microbiologic techniques …

The era of molecular and other non-culture-based methods in diagnosis of sepsis

N Mancini, S Carletti, N Ghidoli, P Cichero… - Clinical microbiology …, 2010 - Am Soc Microbiol
Sepsis, a leading cause of morbidity and mortality throughout the world, is a clinical
syndrome with signs and symptoms relating to an infectious event and the consequent …

Molecular methods for pathogen and microbial community detection and characterization: current and potential application in diagnostic microbiology

CD Sibley, G Peirano, DL Church - Infection, Genetics and Evolution, 2012 - Elsevier
Clinical microbiology laboratories worldwide have historically relied on phenotypic methods
(ie, culture and biochemical tests) for detection, identification and characterization of …

Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis

N Wellinghausen, AJ Kochem, C Disqué… - Journal of clinical …, 2009 - Am Soc Microbiol
In a prospective, multicenter study of 342 blood samples from 187 patients with systemic
inflammatory response syndrome, sepsis, or neutropenic fever, a new commercial PCR test …

Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study

P Tissari, A Zumla, E Tarkka, S Mero, L Savolainen… - The Lancet, 2010 - thelancet.com
Background New DNA-based microarray platforms enable rapid detection and species
identification of many pathogens, including bacteria. We assessed the sensitivity, specificity …

Bacterial sepsis and meningitis

V Nizet, J Klein - Infectious diseases of the fetus and newborn …, 2014 - books.google.com
Bacterial sepsis in the neonate is a clinical syndrome characterized by systemic signs of
infection and accompanied by bacteremia in the first month of life. Meningitis in the neonate …

Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newborns and children with suspected sepsis

B Lucignano, S Ranno, O Liesenfeld… - Journal of clinical …, 2011 - Am Soc Microbiol
Sepsis is a major health problem in newborns and children. Early detection of pathogens
allows initiation of appropriate antimicrobial therapy that strongly correlates with positive …