Epidemiology of uterine fibroids: from menarche to menopause

LA Wise, SK Laughlin-Tommaso - Clinical obstetrics and …, 2016 - journals.lww.com
Uterine leiomyomata (UL) have a substantial impact on women's health, but relatively few
studies have identified opportunities for primary prevention of these neoplasms. Most …

Management of uterine fibroids in pregnancy: recent trends

SG Vitale, F Padula, FA Gulino - Current Opinion in Obstetrics and …, 2015 - journals.lww.com
Myomectomy can increase the rate of pregnancy in women with infertility, attempting to
restore a normal anatomy and reduce uterine contractility and local inflammation associated …

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

N Välimäki, H Kuisma, A Pasanen, O Heikinheimo… - Elife, 2018 - elifesciences.org
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women's health. A
genome-wide association study on 15,453 UL cases and 392,628 controls was performed …

[HTML][HTML] Uterine fibroids—Causes, impact, treatment, and lens to the African perspective

N Sefah, S Ndebele, L Prince, E Korasare… - Frontiers in …, 2023 - frontiersin.org
Leiomyomas, or uterine fibroids as they are commonly known, are mostly seen in women of
reproductive age. However, they can go undetected in most women, and approximately 25 …

A multi-stage genome-wide association study of uterine fibroids in African Americans

JN Hellwege, JM Jeff, LA Wise, CS Gallagher… - Human genetics, 2017 - Springer
Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by
menopause. They are the leading indication for hysterectomy, and account for $34 billion …

Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review

SM Toprani, V Kelkar Mane - Biology of Reproduction, 2021 - academic.oup.com
There has been a significant annual increase in the number of cases of uterine leiomyomas
or fibroids (UF) among women of all races and ages across the world. A fortune is usually …

Evidence that geographic variation in genetic ancestry associates with uterine fibroids

JM Keaton, EA Jasper, JN Hellwege, SH Jones… - Human genetics, 2021 - Springer
Uterine fibroids disproportionately impact Black women. Evidence suggests Black women
have earlier onset and higher cumulative risk. This risk disparity may be due an imbalance …

African genetic ancestry interacts with body mass index to modify risk for uterine fibroids

A Giri, TL Edwards, KE Hartmann, ES Torstenson… - PLoS …, 2017 - journals.plos.org
Race, specifically African ancestry, and obesity are important risk factors for uterine fibroids,
and likely interact to provide the right conditions for fibroid growth. However, existing studies …

Molecular and clinical attributes of uterine leiomyomas

D Dvorská, D Braný, Z Danková, E Halašová… - Tumor …, 2017 - journals.sagepub.com
Uterine leiomyomas, also called uterine fibroids or myomas, represent one of the most
common benign tumour types in women of a fertile age. Leiomyomas arise due to …

Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche

AS Tai, RT Lin, YC Lin, CH Wang, SH Lin… - Human …, 2022 - academic.oup.com
STUDY QUESTION Could the direct contribution of genetic variants to the pathophysiology
of uterine fibroids and the contribution mediated by age at menarche be different …