Podoplanin in inflammation and cancer

M Quintanilla, L Montero-Montero, J Renart… - International journal of …, 2019 - mdpi.com
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

The strategies to cure cancer patients by eradicating cancer stem-like cells

Y Mai, J Su, C Yang, C Xia, L Fu - Molecular Cancer, 2023 - Springer
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2 …

Z Liu, K Wu, S Gu, W Wang, S Xie, T Lu… - Clinical and …, 2021 - Wiley Online Library
Background Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and
treatment‐resistant tumor. The biological implications and molecular mechanism of cancer …

Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma

MY Li, LN Fan, DH Han, Z Yu, J Ma… - The Journal of …, 2020 - Am Soc Clin Investig
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is
highly resistant to current treatments. ESCC harbors a subpopulation of cells exhibiting …

Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer

K Liu, T Zhao, J Wang, Y Chen, R Zhang, X Lan, J Que - Cancer letters, 2019 - Elsevier
Esophageal cancer (EC) has been a leading cause of cancer death worldwide in part due to
late detection and lack of precision treatment. EC includes two major malignancies …

The identifications and clinical implications of cancer stem cells in colorectal cancer

SMR Wahab, F Islam, V Gopalan, AK Lam - Clinical colorectal cancer, 2017 - Elsevier
Cancer stem cells (CSCs) are cancer cells that are responsible for initiation, progression,
metastasis, and recurrence in cancer. The aim of this review was to analyze the markers for …

TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma

SA Khales, S Mozaffari-Jovin, D Geerts… - BMC cancer, 2022 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers
worldwide. Overexpression of EMT master transcription factors can promote differentiated …

Fibroblast growth factor-2–mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma

O Maehara, G Suda, M Natsuizaka, S Ohnishi… - …, 2017 - academic.oup.com
In esophageal squamous cell carcinoma (ESCC), a subset of cells defined by high
expression of CD44 and low expression of CD24 has been reported to possess …

Nonthermal irreversible electroporation to the esophagus: evaluation of acute and long‐term pathological effects in a rabbit model

Y Song, J Zheng, L Fan - Journal of the American Heart …, 2021 - Am Heart Assoc
Background Esophageal ulceration and fistula are severe complications of pulmonary vein
isolation using thermal ablation. Nonthermal irreversible electroporation (NTIRE) is a …

Activation of matrix hyaluronan-mediated CD44 signaling, epigenetic regulation and chemoresistance in head and neck cancer stem cells

LYW Bourguignon, C Earle, M Shiina - International journal of molecular …, 2017 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a
genotypically and phenotypically heterogeneous population of neoplastic cells types. High …