The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on
elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB …

Doxorubicin is a highly effective chemotherapeutic agent widely used to treat a variety of
cancers. However, the clinical application of doxorubicin is limited due to its adverse effects …

Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the
treatment of numerous malignancies. The primary dose-limiting adverse effect of …

Key points Although doxorubicin is a highly effective anti‐tumour agent, the administration of
this drug is associated with significant side effects, including contractile dysfunction and …

The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically
remodels during cardiac disease. This review examines DGC remodeling as a common …

The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative
stress, disruption of calcium homeostasis and activation of cardiomyocyte death …

Doxorubicin (DOX) is a boon for cancer‐suffering patients. However, the undesirable effect
on health on vital organs, especially the heart, is a limiting factor, resulting in an increased …

Functional changes in the heart in patients with cancer can be a result of both the disease
itself and various cancer therapies, and limiting cardiac damage has become an …

Objectives Doxorubicin (DXR), an anthracyclic antineoplastic agent, is one of the most
commonly drug utilized to induce dilated cardiomyopathy (DCM) and heart failure (HF), but …

Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking
predictability of animal models. Additionally, risk of cardiotoxicity following treatment of …