Design, synthesis, and utility of defined molecular scaffolds
A growing theme in chemistry is the joining of multiple organic molecular building blocks to
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …
create functional molecules. Diverse derivatizable structures—here termed “scaffolds” …
Indoxyl-glucosides bearing tethers for enzymatically triggered cross-linking
Indoxyl-glucosides upon treatment with β-glucosidase under physiological conditions are
well known to afford the corresponding indigoid dye via oxidative dimerization. Here, seven …
well known to afford the corresponding indigoid dye via oxidative dimerization. Here, seven …
Chemically triggered hydrogel transformations through covalent adaptable networks and applications in cell culture
In this article, we report a “smart” hydrogel system, which can be remodeled into multiple
architectures through dynamic covalent adaptable networks. The topological changes in …
architectures through dynamic covalent adaptable networks. The topological changes in …
Tethered indoxyl-glucuronides for enzymatically triggered cross-linking
Indoxyl-glucuronides, upon treatment with β-glucuronidase under physiological conditions,
are well known to afford the corresponding indigoid dye via oxidative dimerization. Here …
are well known to afford the corresponding indigoid dye via oxidative dimerization. Here …
Tailoring the AIE Chromogen 2-(2-Hydroxyphenyl) benzothiazole for Use in Enzyme-Triggered Molecular Brachytherapy
A targeted strategy for treating cancer is antibody-directed enzyme prodrug therapy, where
the enzyme attached to the antibody causes conversion of an inactive small-molecule …
the enzyme attached to the antibody causes conversion of an inactive small-molecule …
Bicyclo [6.1. 0] nonyne carboxylic acid for the production of stable molecular probes
Bicyclo [6.1. 0] non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne
scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue …
scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue …
Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions
An “A2BC”-type bioconjugatable compound (1) that enables enzymatically triggered cross-
linking chemistry has been designed and synthesized. The compound contains two indoxyl …
linking chemistry has been designed and synthesized. The compound contains two indoxyl …
Synthesis and stability studies of bicyclo [6.1. 0] nonyne scaffolds for automated solid-phase oligonucleotide synthesis
K Karalė, M Bollmark, A Karalius, M Lopes, O Pérez… - RSC …, 2024 - pubs.rsc.org
Two novel bicyclo [6.1. 0] nonyne (BCN) linker derivatives, which can be directly
incorporated into oligonucleotide sequences during standard automated solid-phase …
incorporated into oligonucleotide sequences during standard automated solid-phase …
Peptide-based scaffolds for in vivo immobilization and enzyme attachment in therapeutic applications
DL Lee, HLM Chin, CG Knudsen… - … and Nano Machines …, 2020 - spiedigitallibrary.org
Advances in molecular design and synthetic chemistry enable the development of novel
molecular therapeutic treatments of diverse diseases. A strategy proposed nearly 25 years …
molecular therapeutic treatments of diverse diseases. A strategy proposed nearly 25 years …
Engineering of an archaeal phosphodiesterase to trigger aggregation-induced emission (AIE) of synthetic substrates
Y Zhang, Z Wu, I Takashima, KU Nguyen… - New Journal of …, 2020 - pubs.rsc.org
Aggregation-induced emission (AIE) probes that can be triggered by enzymatic activity are
sought for applications across the life sciences. The compound 2-(2-hydroxyphenyl) …
sought for applications across the life sciences. The compound 2-(2-hydroxyphenyl) …