The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …

Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a
phosphatase/phosphotransferase family. Mammalian LPPs consist of three isoforms: LPP1 …

Summary Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and
plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made …

The signaling lipid sphingosine-1-phosphate (S1P) stabilizes the vasculature, directs
lymphocyte egress from lymphoid organs, and shapes inflammatory responses. However …

Granule cell migration influences the laminar structure of the cerebellum and thereby affects
cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell …

Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong
to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum …

Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of
coronary artery disease (CAD) and the causal mechanisms at the majority of loci are …

Objective—Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an
integral membrane enzyme that dephosphorylates, and thereby terminates, the G-protein …

Signaling by the bioactive sphingolipid, sphingosine 1–phosphate (S1P), and its precursors
are emerging areas in pregnancy research. S1P and ceramide levels increase towards end …

Despite the importance of signaling lipids, many questions remain about their function
because few tools are available for charting lipid gradients in vivo. Here we generated a …