Simple Summary CA125 has been the most promising biomarker for screening ovarian
cancer; however, it still does not have an acceptable accuracy in population-based …

Simple Summary Ovarian high-grade serous carcinoma (HGSC) has a 5-year survival rate
of less than 50%, making it one of the most lethal gynecological cancers for women in the …

Exploiting the burgeoning fields of genomics, proteomics and metabolomics improves
understanding of human physiology and, critically, the mutations that signal disease …

Introduction: The advent of high throughput technologies capable of comprehensive
analysis of genes, transcripts, proteins and other significant biological molecules has …

Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …

The progression of ovarian cancer, from cell transformation through invasion of normal
tissue, relies on communication between tumor cells and their adjacent stromal …

Background: The aim of this work was to analyze the diagnostic and prognostic value of
serum human epididymis protein 4 (HE4) and Risk for Ovarian Malignancy Algorithm …

Each year in the United States over 15,000 women die of epithelial ovarian cancer (EOC)
and 22,000 are diagnosed with the disease. The incidence of ovarian cancer has remained …

The current lack of an accurate, cost-effective and non-invasive test that would allow for
screening and diagnosis of gynaecological carcinomas, such as endometrial and ovarian …

This paper reviews current screening techniques as well as novel biomarkers and their
potential role in early detection of ovarian cancer. Ovarian cancer is one of the most …