E Mracsko, R Veltkamp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which no specific treatment has been established yet. Although preclinical models of ICH have …
CL MacLellan, G Silasi, CC Poon… - Journal of Cerebral …, 2008 - journals.sagepub.com
Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A greater understanding of stroke pathophysiology is needed to successfully develop …
J Ruan, Y Yao - Brain hemorrhages, 2020 - Elsevier
Rodents are the most widely used experimental animals in stroke research due to their similar vascular anatomy, high reproductive rates, and availability of transgenic models …
L Xiao, H Zheng, J Li, M Zeng, D He, J Liang… - Biomedicine & …, 2022 - Elsevier
Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …
Microglia/macrophages (MMΦ) are highly plastic phagocytes that can promote both injury and repair in diseased brain through the distinct function of classically activated and …
PR Krafft, EL Bailey, T Lekic… - … Journal of stroke, 2012 - journals.sagepub.com
Animal models of stroke contribute to the development of better stroke prevention and treatment through studies investigating the pathophysiology of different stroke subtypes and …
H Sun, X He, X Tao, T Hou, M Chen, M He… - Journal of …, 2020 - Springer
Background Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism …