Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of
the highest fatality rates of any disease. There are many clinical signs and symptoms after …

Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …

Many therapies have shown promise in preclinical stroke studies, but few benefit patients. A
greater understanding of stroke pathophysiology is needed to successfully develop …

Rodents are the most widely used experimental animals in stroke research due to their
similar vascular anatomy, high reproductive rates, and availability of transgenic models …

T-lymphocytes promote cerebral inflammation, thus aggravating neuronal injury after stroke.
Fingolimod, a sphingosine 1-phosphate receptor analog, prevents the egress of …

Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus
on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …

Microglia/macrophages (MMΦ) are highly plastic phagocytes that can promote both injury
and repair in diseased brain through the distinct function of classically activated and …

Background. Enriched rehabilitation (ER; environmental enrichment plus skilled reaching)
improves recovery after middle cerebral artery occlusion (MCAo) in rats. Fundamental …

Animal models of stroke contribute to the development of better stroke prevention and
treatment through studies investigating the pathophysiology of different stroke subtypes and …

Background Spontaneous functional recovery occurs during the acute phase after stroke
onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism …