Treatment of nonalcoholic fatty liver disease: role of AMPK

BK Smith, K Marcinko, EM Desjardins… - American Journal …, 2016 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

Plant‐based foods and their bioactive compounds on fatty liver disease: Effects, mechanisms, and clinical application

HY Li, RY Gan, A Shang, QQ Mao… - Oxidative medicine …, 2021 - Wiley Online Library
Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic
fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of …

Natural compounds for counteracting nonalcoholic fatty liver disease (NAFLD): advantages and limitations of the suggested candidates

N Salvoza, PJ Giraudi, C Tiribelli, N Rosso - International Journal of …, 2022 - mdpi.com
The booming prevalence of nonalcoholic fatty liver disease (NAFLD) in adults and children
will threaten the health system in the upcoming years. The “multiple hit” hypothesis is the …

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

R Domitrović, I Potočnjak - Archives of toxicology, 2016 - Springer
Hepatoprotective effects of natural compounds have been frequently attributed to their
antioxidant properties and the ability to mobilize endogenous antioxidant defense system …

Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling

Y Wang, C Li, J Gu, C Chen, J Duanmu… - Journal of Cellular …, 2020 - Wiley Online Library
Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent
liver protection effects on several liver‐related diseases. However, the anti‐inflammatory …

Mechanisms of action of coffee bioactive components on lipid metabolism

R Farias-Pereira, CS Park, Y Park - Food Science and Biotechnology, 2019 - Springer
Coffee consumption is associated with reduced risk of metabolic syndrome, obesity and
diabetes, which may be related to the effects of coffee and its bioactive components on lipid …

Berberine ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats via activation of SIRT3/AMPK/ACC pathway

Y Zhang, Y Deng, K Tang, R Chen, S Liang… - Current medical …, 2019 - Springer
This study aimed to verify the effects of berberine (BBR) on the fat metabolism proteins
involved in the sirtuin 3 (SIRT3)/adenosine 5'-monophosphate (AMP)-activated protein …

Chlorogenic acid modulates autophagy by inhibiting the activity of ALKBH5 demethylase, thereby ameliorating hepatic steatosis

F Meng, C Song, J Liu, F Chen, YH Zhu… - Journal of Agricultural …, 2023 - ACS Publications
Chlorogenic acid (CGA) is a naturally occurring plant component with the purpose of
alleviating hepatic lipid deposition biological activities. However, the molecular mechanism …

Berberine alleviates nonalcoholic fatty liver induced by a high‐fat diet in mice by activating SIRT3

X Xu, XP Zhu, JY Bai, P Xia, Y Li, Y Lu… - The FASEB …, 2019 - Wiley Online Library
Berberine (BBR) shows promising effects in the treatment of nonalcoholic fatty liver disease
(NAFLD) by influencing various metabolic aspects. Inhibition of mitochondrial β‐oxidation (β …

[HTML][HTML] Low-level Nd: YAG laser inhibiting inflammation and oxidative stress in human gingival fibroblasts via AMPK/SIRT3 axis

H Zhang, C Zhang, L Pan, Y Chen, Z Bian… - … of Photochemistry and …, 2024 - Elsevier
Objective Photobiomodulation is extensively employed in the management of chronic
inflammatory diseases such as periodontitis because of its anti-inflammatory and antioxidant …