Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Recent advances in understanding the molecular pathophysiology of angiotensin II receptors; lessons from cell-selective receptor deletion in mice
The renin-angiotensin system (RAS) is an essential hormonal system involved in water and
sodium reabsorption, renal blood flow regulation, and arterial constriction. Systemic …
sodium reabsorption, renal blood flow regulation, and arterial constriction. Systemic …
Angiotensin II type 1A receptor expressed in smooth muscle cells is required for hypertensive vascular remodeling in mice infused with angiotensin II
K Okuno, K Torimoto, SM Cicalese, K Preston… - …, 2023 - Am Heart Assoc
Background: Ang II (angiotensin II) type 1 (AT1) receptors play a critical role in
cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …
cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …
The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System
M Colin, C Delaitre, S Foulquier, F Dupuis - Molecules, 2023 - mdpi.com
The AT1 receptor has mainly been associated with the pathological effects of the renin-
angiotensin system (RAS)(eg, hypertension, heart and kidney diseases), and constitutes a …
angiotensin system (RAS)(eg, hypertension, heart and kidney diseases), and constitutes a …
Insights Into the Role of Angiotensin-II AT1 Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease
β-arrestins are a family of intracellular signaling proteins that play a key role in regulating the
activity of G protein-coupled receptors. The angiotensin-II type 1 receptor is an important G …
activity of G protein-coupled receptors. The angiotensin-II type 1 receptor is an important G …
Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts
W Parichatikanond, R Duangrat, S Mangmool - European Journal of …, 2023 - Elsevier
Angiotensin II receptors are members of G protein-coupled receptor superfamily that
manifest biased signals toward G protein-and β-arrestin-dependent pathways. However, the …
manifest biased signals toward G protein-and β-arrestin-dependent pathways. However, the …
Role of transient receptor potential channels in the regulation of vascular tone
Vascular tone is a major element in the control of hemodynamics. Transient receptor
potential (TRP) channels conducting monovalent and/or divalent cations (eg Na+ and Ca …
potential (TRP) channels conducting monovalent and/or divalent cations (eg Na+ and Ca …
Arterial myogenic response and aging
Y Cui, M Gollasch, M Kassmann - Ageing Research Reviews, 2023 - Elsevier
The arterial myogenic response is an inherent property of resistance arteries. Myogenic tone
is crucial for maintaining a relatively constant blood flow in response to changes in …
is crucial for maintaining a relatively constant blood flow in response to changes in …
Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure
NM Mathieu, EE Tan, JJ Reho, DT Brozoski… - …, 2024 - Am Heart Assoc
BACKGROUND: ANG (angiotensin II) elicits dipsogenic and pressor responses via
activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 …
activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 …
A new model for evaluating pressure-induced vascular tone in small cerebral arteries
The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a
fundamental physiological role and appears to be relevant in different pathological …
fundamental physiological role and appears to be relevant in different pathological …