The renin-angiotensin system (RAS) is an essential hormonal system involved in water and sodium reabsorption, renal blood flow regulation, and arterial constriction. Systemic …
K Okuno, K Torimoto, SM Cicalese, K Preston… - …, 2023 - Am Heart Assoc
Background: Ang II (angiotensin II) type 1 (AT1) receptors play a critical role in cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …
M Colin, C Delaitre, S Foulquier, F Dupuis - Molecules, 2023 - mdpi.com
The AT1 receptor has mainly been associated with the pathological effects of the renin- angiotensin system (RAS)(eg, hypertension, heart and kidney diseases), and constitutes a …
β-arrestins are a family of intracellular signaling proteins that play a key role in regulating the activity of G protein-coupled receptors. The angiotensin-II type 1 receptor is an important G …
Angiotensin II receptors are members of G protein-coupled receptor superfamily that manifest biased signals toward G protein-and β-arrestin-dependent pathways. However, the …
XQ Hu, L Zhang - Drug Discovery Today, 2024 - Elsevier
Vascular tone is a major element in the control of hemodynamics. Transient receptor potential (TRP) channels conducting monovalent and/or divalent cations (eg Na+ and Ca …
Y Cui, M Gollasch, M Kassmann - Ageing Research Reviews, 2023 - Elsevier
The arterial myogenic response is an inherent property of resistance arteries. Myogenic tone is crucial for maintaining a relatively constant blood flow in response to changes in …
NM Mathieu, EE Tan, JJ Reho, DT Brozoski… - …, 2024 - Am Heart Assoc
BACKGROUND: ANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 …
The capacity of small cerebral arteries (SCAs) to adapt to pressure fluctuations has a fundamental physiological role and appears to be relevant in different pathological …