SFPQ promotes an oncogenic transcriptomic state in melanoma

O Bi, CA Anene, J Nsengimana, M Shelton, W Roberts… - Oncogene, 2021 - nature.com
The multifunctional protein, splicing factor, proline-and glutamine-rich (SFPQ) has been
implicated in numerous cancers often due to interaction with coding and non-coding RNAs …

[HTML][HTML] Fourier-Transform InfraRed (FT-IR) spectroscopy to show alterations in molecular composition of EV subpopulations from melanoma cell lines in different …

E Stępień, A Kamińska, M Surman… - … and Biophysics Reports, 2021 - Elsevier
Background Melanoma cells release extracellular vesicles (EVs) subpopulations which
differ in size, phenotype and molecular content. Melanoma derived EVs play a role in the …

Intrinsic disorder and flexibility in proteins: a challenge for structural biology and drug design

G Zanotti - Crystallography Reviews, 2023 - Taylor & Francis
The structure–function paradigm, ie the concept that it is the three-dimensional structure of a
protein that determines its function, has been partially modified by the discovery that a …

Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma

L Zhong, W Qian, W Gong, L Zhu… - Cellular and Molecular …, 2023 - mail.cellmolbiol.org
Cutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further
risk stratification and search for new prognostic targets for CM are of positive clinical …

A Computational Approach to Characterize the Protein S-Mer Tyrosine Kinase (PROS1-MERTK) Protein-Protein Interaction Dynamics

MB Djulbegovic, DJT Gonzalez, L Laratelli… - Cell biochemistry and …, 2024 - Springer
Protein S (PROS1) has recently been identified as a ligand for the TAM receptor MERTK,
influencing immune response and cell survival. The PROS1–MERTK interaction plays a role …

Comparative Analysis of the Intrinsic Disorder Within the Layers of the Human Cornea

MB Djulbegovic, M Antonietti, DJT Gonzalez, R Mattes… - Cornea, 2025 - journals.lww.com
Purpose: The human cornea is essential for vision, providing structural integrity and
refractive power to the eye. Recent advancements have deepened our understanding of the …

Screening and identification of potential biomarkers and therapeutic drugs in melanoma via integrated bioinformatics analysis

B Chen, D Sun, X Qin, XH Gao - Investigational New Drugs, 2021 - Springer
Melanoma is a highly aggressive malignant skin tumor with a high rate of metastasis and
mortality. In this study, a comprehensive bioinformatics analysis was used to clarify the hub …

[HTML][HTML] 基于生物信息学探讨杜仲叶治疗癫痫的作用机制和物质基础

魏明星, 唐文雅, 张帅男, 李煦照 - Hans Journal of Biomedicine, 2024 - hanspub.org
目的: 基于生物信息学技术研究杜仲叶治疗癫痫的作用机制和物质基础. 方法: 运用LC-MS
技术获得杜仲叶成分, 并通过SuperPred 数据库和GeneCards 等数据库获得成分和疾病靶点 …