DNA-origami-based precise molecule assembly and their biological applications

G Li, C Chen, Y Li, B Wang, J Wen, M Guo, M Chen… - Nano Letters, 2024 - ACS Publications
Inspired by efficient natural biomolecule assembly with precise control on key parameters
such as distance, number, orientation, and pattern, the constructions and applications of …

Framework Nucleic Acid‐Based Selective Cell Catcher for Endogenous Stem Cell Recruitment

X Chen, Z Xu, Y Gao, Y Chen, W Yin, Z Liu… - Advanced …, 2024 - Wiley Online Library
Cell‐surface engineering holds great promise in boosting endogenous stem cell attraction
for tissue regeneration. However, challenges such as cellular internalization of ligand and …

DNA-modulated dimerization and oligomerization of cell membrane receptors

AA Ali, M You - Chemical Communications, 2024 - pubs.rsc.org
DNA-based nanostructures and nanodevices have recently been employed for a broad
range of applications in modulating the assemblies and interaction patterns of different cell …

Label-Free Mapping of Multivalent Binding Pathways with Ligand–Receptor-Anchored Nanopores

H Ma, Y Wang, YX Li, BK Xie, ZL Hu… - Journal of the …, 2024 - ACS Publications
Understanding single-molecule multivalent ligand–receptor interactions is crucial for
comprehending molecular recognition at biological interfaces. However, label-free …

Insulin-inspired hippocampal neuron–targeting technology for protein drug delivery

N Kamei, K Ikeda, Y Ohmoto, S Fujisaki… - Proceedings of the …, 2024 - pnas.org
Hippocampal neurons can be the first to be impaired with neurodegenerative disorders,
including Alzheimer's disease (AD). Most drug candidates for causal therapy of AD cannot …

Investigation and Regulation of DNA Nanostructures on Activating cGAS‐STING Signaling

K Zou, P Zhang, Y Wang, Y Liu, B Ji, P Zhan… - Small …, 2024 - Wiley Online Library
DNA nanostructures have shown great potential in biomedical fields. However, the immune
responses, especially the activation of the cGAS‐STING signaling (A‐cGSs), induced by …

Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules

SW Nooteboom, KR Okholm, V Lamberti, B Oomen… - Nano Letters, 2024 - ACS Publications
Single-molecule fluorescence has revealed a wealth of biochemical processes but does not
give access to submillisecond dynamics involved in transient interactions and molecular …

Purification of DNA Nanoparticles Using Photocleavable Biotin Tethers

HR Everson, K Neyra, DV Scarton… - … Applied Materials & …, 2024 - ACS Publications
The number of applications of self-assembled deoxyribonucleic acid (DNA) origami
nanoparticles (DNA NPs) has increased drastically, following the development of a variety of …

Programmable Circular Multispecific Aptamer-Drug Engager to Broadly Boost Antitumor Immunity

J Chen, H Chi, C Wang, Y Du, Y Wang… - Journal of the …, 2024 - ACS Publications
Safely and effectively harnessing innate immunity to boost cancer immunotherapy is
promising yet challenging. Hence, we have developed a series of programmable aptamer …

Rationally Designing the Supramolecular Interfaces of Nanoparticle Superlattices with Multivalent Polymers

CJ Thrasher, F Jia, DW Yee, JM Kubiak… - Journal of the …, 2024 - ACS Publications
In supramolecular materials, multiple weak binding groups can act as a single collective unit
when confined to a localized volume, thereby producing strong but dynamic bonds between …