Therapeutic agents and biocides for ocular infections by free-living amoebae of Acanthamoeba genus

LC Carrijo-Carvalho, VP Sant'ana, AS Foronda… - survey of …, 2017 - Elsevier
Acanthamoeba keratitis is a sight-threatening infectious disease. Resistance of the cystic
form of the protozoan to biocides and the potential toxicity of chemical compounds to corneal …

[PDF][PDF] Acanthamoeba

NA Khan - Biology and pathogenesis, 2009 - caister.com
1. A host for viruses 2. A host for yeast 3. A host for protists 4. Acanthamoeba and bacteria
interactions 5. Is Acanthamoebaan evolutionary ancestor of macrophages? 6 …

Corneal infections in the 21st century

HS Ong, MC Corbett - Postgraduate Medical Journal, 2015 - academic.oup.com
Ninety years ago, the first issue of the Postgraduate Medical Journal published a review of
an article written by Mr Robert Lindsay-Rea, a consultant ophthalmic surgeon in the Western …

Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years

W List, W Glatz, R Riedl, G Mossboeck… - Scientific Reports, 2021 - nature.com
To report on Acanthamoeba keratitis cases in a tertiary university eye-hospital in Graz,
Austria, over a 21-year period. Retrospective study. Parameters included demographics …

Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri

A Anwar, MR Mungroo, A Anwar… - ACS Infectious …, 2019 - ACS Publications
Brain-eating amoebae cause devastating infections in the central nervous system of
humans, resulting in a mortality rate of 95%. There are limited effective therapeutic options …

Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii

CM Martín-Navarro, A López-Arencibia… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight-
threatening keratitis and a life-threatening encephalitis. In order to treat those infections …

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

S Thomson, CA Rice, T Zhang, RA Edrada-Ebel… - Scientific reports, 2017 - nature.com
The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-
threatening infection of the eye and the almost universally fatal granulomatous amoebic …

[HTML][HTML] Pitavastatin loaded nanoparticles: a suitable ophthalmic treatment for Acanthamoeba Keratitis inducing cell death and autophagy in Acanthamoeba …

I Sifaoui, P Díaz-Rodríguez… - European Journal of …, 2022 - Elsevier
Statins are effective sterol lowering agents with high amoebicidal activity. Nevertheless, due
to their poor aqueous solubility, they remain underused especially in eye drop formulation …

Acanthamoeba sclerokeratitis: epidemiology, clinical features, and treatment outcomes

A Iovieno, DM Gore, N Carnt, JK Dart - Ophthalmology, 2014 - Elsevier
Purpose To describe the epidemiology, clinical features, and treatment outcomes of
Acanthamoeba sclerokeratitis (ASK). Design Retrospective case series. Participants All …

Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic Pathogen Acanthamoeba castellanii

N Akbar, MI El-Gamal, BQ Saeed, CH Oh… - Antibiotics, 2022 - mdpi.com
We examined the antiamoebic effect of several imidazothiazole derivatives on
Acanthamoeba castellanii of the T4 genotype. Trypan blue exclusion assays and …