The spiral ligament in the cochlea has been suggested to play a significant role in the
pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes …

The cochlea of the mammalian inner ear contains an endolymph that exhibits an
endocochlear potential (EP) of+ 80 mV with a [K+] of 150 mM. This unusual extracellular …

The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is
necessary for proper hair cell mechanotransduction and hearing. While channels belonging …

Real-time recording of the kinetics of systemically administered drugs in in vivo
microenvironments may accelerate the development of effective medical therapies …

Background: The cochlea produces an electric field potential essential for hair cell
transduction and hearing. This biological “battery” is situated in the lateral wall of the …

Eukaryotic cells exhibit negative resting membrane potential (RMP) owing to the high K+
permeability of the plasma membrane and the asymmetric [K+] between the extracellular …

Excitable cochlear hair cells convert the mechanical energy of sounds into the electrical
signals necessary for neurotransmission. The key process is cellular depolarization via K+ …

Background Furosemide is a loop diuretic used to treat edema; however, it also targets the
Na-K-Cl cotransporter-1 (NKCC1) in the inner ear. In very high doses, furosemide abolishes …

Interdisciplinary collaboration among various fields is essential for advancements in
science. In medicine, innovative approaches created through the collaboration are required …

Identification of the causal effects of specific proteins on recurrent and partially reversible
hearing loss has been difficult because of the lack of an animal model that provides …