In this paper, a compression behavior classification system (CBCS) for direct compression
(DC) pharmaceutical powders is presented. Seven descriptors from a series of compression …

Predicting tablet defects, such as capping, that might occur during manufacturing, is a
challenge in the pharmaceutical industry. In the literature, different parameters were …

The study evaluated the performance of various machine learning methods in predicting
tensile strength of microwave post-cured composite tailored for weight-sensitive …

In a recent study, it was demonstrated that improving flow of a model poorly flowing and
poorly compactable drug substance, acetaminophen, via dry coating while using fine …

In this work, the transfer of oral solid dosage forms, currently manufactured via wet
granulation, to a continuous direct compression process was considered. Two main …

The evolution of microstructure during powder compaction process was investigated using a
discrete particle modeling, which accounts for particle size distribution and material …

A mechanistic particle scale model is proposed for bilayer tablet compaction. Making bilayer
tablets involves the application of first layer compaction pressure on the first layer powder …

We present generalized loading-unloading contact laws for elasto-plastic spheres with
bonding strength. The proposed mechanistic contact laws are continuous at the onset of …

The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires
numerous processes during which there is risk of dissociation into parent molecules …

We adopt a Quality by Design (QbD) paradigm to better control the mechanical properties of
tablets. To this end, the effect of particle size distribution, lubricant concentration, and mixing …