Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that
develop from distinct epithelial sub-types; however, they are both related to chronic …

Barrett's esophagus (BE) is the strongest risk factor for esophageal adenocarcinoma (EAC),
a malignancy with persistently poor long-term outcomes. EAC is thought to develop through …

Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2
protein expression and gene amplification in patients with curatively resected esophageal …

Esophageal adenocarcinomas are poorly responsive to chemotherapeutics. This study
aimed to determine the levels of Aurora kinase A (AURKA) and the therapeutic potential of …

Vitamin D deficiency and low calcium intake are considered risk factors for several cancers.
Vitamin D, synthesized in the skin or ingested through the diet, is transformed through two …

A growing body of evidence indicates that miRNAs may be a class of genetic elements that
can either drive or suppress oncogenesis. In this study we analyzed the somatic copy …

OBJECTIVES: The assessment of cancer risk in patients with Barrett's esophagus (BE) is
currently fraught with difficulty. The current gold standard method of assessing cancer risk is …

Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is
uncommon but the consequences are serious. Predictors of progression are essential to …

BACKGROUND: Upper gastrointestinal adenocarcinomas (UGCs) respond poorly to current
chemotherapeutic regimes. The authors and others have previously reported frequent …

Objective The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is
low and difficult to predict. Accurate tools for risk stratification are needed to increase the …