Studies of transcriptional mechanisms in heart failure have focused heavily on roles of
sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4. Recent findings …

DNA modification is known to regulate experience-dependent gene expression. However,
beyond cytosine methylation and its oxidated derivatives, very little is known about the …

Germ-line mutations in breast cancer susceptibility gene 1 (BRCA1) predominantly
predispose women to breast and ovarian cancers. BRCA1 is best known for its functions in …

Abstract Promoter-proximal RNA Pol II pausing is a critical step in transcriptional control. Pol
II pausing has been predominantly studied in tissue culture systems. While Pol II pausing …

Abstract T cell factor 1 (TCF1) is required for memory and stem-like CD8+ T cell functions.
How TCF1 partners with other transcription factors to regulate transcription remains unclear …

Cancer cells undergo transcriptional reprogramming to drive tumor progression and
metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate …

Aims/hypothesis Better understanding of how genetic and epigenetic components control
beta cell differentiation and function is key to the discovery of novel therapeutic approaches …

Gene expression is tightly regulated during hematopoiesis. Recent studies have suggested
that RNA polymerase II (Pol II) promoter proximal pausing, a temporary stalling downstream …

Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of disease, ranging
from simple fatty liver through steatosis with inflammation and necrosis to cirrhosis. One of …

Materials and methods Generation of zkscan3 knockout mice by the CRISPR/Cas9 method
zkscan3 knockout mice were generated using the CRISPR/Cas9 method as reported …