Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …

Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in
epigenetic machinery have become a major focus for targeted therapies. The current report …

Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …

A plethora of groundbreaking studies have demonstrated the importance of chromatin-
associated proteins and post-translational modifications of histones, proteins and DNA (so …

Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid
leukemia (AML) with MLL translocations. The assumption has been that differentiation is …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

The long non-coding RNA Hox transcript antisense intergenic RNA (HOTAIR) was recently
implicated in breast cancer metastasis and is predictive of poor prognosis in colorectal and …

Histone lysine‐specific demethylase 1 (LSD1) is the first discovered and reported histone
demethylase by Dr. Shi Yang's group in 2004. It is classified as a member of amine oxidase …

PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A),
with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety …