3-3 proteins are a family of structurally similar phospho-binding proteins that regulate
essentially every major cellular function. Decades of research on 14-3-3s have revealed a …

The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints
preserve genome integrity. Central to these genome surveillance pathways is a protein …

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and
fidelity of the major events of the cell cycle. These include growth to the appropriate cell size …

▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of
the eukaryotic cell division cycle and have also been implicated in the control of gene …

Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …

In response to DNA damage, mammalian cells prevent cell cycle progression through the
control of critical cell cycle regulators. A human gene was identified that encodes the protein …

Control of eukaryotic cell proliferation involves an extended regulatory network, the
complexity of which has made it difficult to understand the basic principles of the cell cycle …

The hCHK2 gene encodes the human homolog of the yeast Cds1 and Rad53 G2 checkpoint
kinases, whose activation in response to DNA damage prevents cellular entry into mitosis …

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial
breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular …

The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—
a motif that is found in many proteins that are implicated in DNA damage response and in …