The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Metastasis is an evolutionary process occurring across multiple organs and timescales. Due
to its continuous and dynamic nature, this multifaceted process has been challenging to …

Accurate segmentation and tracking of cells in microscopy image sequences is extremely
beneficial in clinical diagnostic applications and biomedical research. A continuing …

Rodent models of breast cancer have played critical roles in our understanding of breast
cancer development and progression as well as preclinical testing of cancer prevention and …

Breast tumors overexpressing human epidermal growth factor receptor (HER2) confer
intrinsic resistance to endocrine therapy (ET), and patients with HER2/estrogen receptor …

In breast cancer, epithelial-mesenchymal transition (EMT) is positively associated with
programmed death ligand 1 (PD-L1) expression and immune escape, and TWIST1 silences …

Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies
and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of …