Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Mitochondria, which serve as the energy factories of cells, are involved in cell differentiation,
calcium homeostasis, amino acid and fatty acid metabolism and apoptosis. In response to …

The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …

SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine
methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 …

Understanding of the appropriate regulation of enzymatic activities of histone‐modifying
enzymes remains poor. The lysine methyltransferase, SETDB1, is one of the enzymes …

Genomic regions preferentially associate with regions of similar transcriptional activity,
partitioning genomes into active and inactive compartments within the nucleus. Here we …

Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9
(H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show …

The establishment and maintenance of chromatin domains shape the epigenetic memory of
a cell, with the methylation of histone H3 lysine 9 (H3K9me) defining transcriptionally silent …

Sex determination in the nematode C. elegans is controlled by the master regulator XOL-1
during embryogenesis. Expression of xol-1 is dependent on the ratio of X chromosomes and …

Abstract Eggless/SETDB 1 (Egg), the only essential histone methyltransferase (HMT) in
Drosophila, plays a role in gene repression, including pi RNA‐mediated transposon …