Hippo pathway in organ size control, tissue homeostasis, and cancer
Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …
An insight into the cancer stem cell survival pathways involved in chemoresistance in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …
Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
A Gregorieff, Y Liu, MR Inanlou, Y Khomchuk… - Nature, 2015 - nature.com
The gut epithelium has remarkable self-renewal capacity that under homeostatic conditions
is driven by Wnt signalling in Lgr5+ intestinal stem cells (ISCs). However, the mechanisms …
is driven by Wnt signalling in Lgr5+ intestinal stem cells (ISCs). However, the mechanisms …
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation
contributes to tumorigenesis. Core components of the Hippo pathway include a kinase …
contributes to tumorigenesis. Core components of the Hippo pathway include a kinase …
Mechanisms of Hippo pathway regulation
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue
growth two decades ago and has been a subject extensively studied in both Drosophila and …
growth two decades ago and has been a subject extensively studied in both Drosophila and …
Characterization of Hippo pathway components by gene inactivation
The Hippo pathway is important for regulating tissue homeostasis, and its dysregulation has
been implicated in human cancer. However, it is not well understood how the Hippo …
been implicated in human cancer. However, it is not well understood how the Hippo …
The Hippo pathway in intestinal regeneration and disease
The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury
F Deng, L Peng, Z Li, G Tan, E Liang, S Chen… - Cell death & …, 2018 - nature.com
Impaired epithelial regeneration is a crucial pathophysiological feature of ulcerative colitis
(UC). Yes-associated protein (YAP1) appears to control cell proliferation and differentiation …
(UC). Yes-associated protein (YAP1) appears to control cell proliferation and differentiation …
Selective inhibition of STRN3-containing PP2A phosphatase restores hippo tumor-suppressor activity in gastric cancer
Y Tang, G Fang, F Guo, H Zhang, X Chen, L An… - Cancer Cell, 2020 - cell.com
Loss of Hippo tumor-suppressor activity and hyperactivation of YAP are commonly observed
in cancers. Inactivating mutations of Hippo kinases MST1/2 are uncommon, and it remains …
in cancers. Inactivating mutations of Hippo kinases MST1/2 are uncommon, and it remains …
Disease implications of the Hippo/YAP pathway
The Hippo signaling pathway is important for controlling organ size and tissue homeostasis.
Originally identified in Drosophila melanogaster, the core components of the Hippo pathway …
Originally identified in Drosophila melanogaster, the core components of the Hippo pathway …