Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

The effectiveness of the annual influenza vaccine has declined in recent years, especially
for the H3N2 component, and is a concern for global public health. A major cause for this …

The development of clinically useful peptide‐based vaccines remains a long‐standing goal.
This review highlights that intrinsically disordered protein antigens, which lack an ordered …

Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

Asparaginyl endopeptidases (AEPs) are a class of enzymes commonly associated with
proteolysis in the maturation of seed storage proteins. However, a subset of AEPs work …

Disordered proteins are important antigens in a range of infectious diseases. Little is known,
however, about the molecular details of recognition of disordered antigens by their cognate …

Malaria remains a significant global health burden. The development of an effective malaria
vaccine remains as a major challenge with the potential to significantly reduce morbidity and …

Plasmodium falciparum vaccine RTS, S/AS01 is based on the major NPNA repeat and the C-
terminal region of the circumsporozoite protein (CSP). RTS, S-induced NPNA-specific …

A growing body of evidence supports the hypothesis that intrinsically disordered proteins
often mediate host–pathogen interactions and modulate host functions for pathogen survival …

Conformational diversity and self-cross-reactivity of antigens have been correlated with
evasion from neutralizing antibody responses. We utilized single cell B cell sequencing …