Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and
for the treatment of opioid dependence. The pharmacokinetics of methadone differ from …

Many marketed drugs are chiral and are administered as the racemate, a 50: 50
combination of two enantiomers. Pharmacodynamic and pharmacokinetic differences …

Background: This topical review addresses methadone's pharmacology, its application in
malignant and non‐malignant pain conditions, practical issues related to methadone for the …

Opioid analgesics are commonly prescribed for acute and chronic pain, but are subject to
abuse. Consequently, toxicology testing programs are frequently implemented for both …

Objectives. To develop evidence-based practice guidelines for the pharmacological
treatment of opioid abuse and dependence. Methods. An international task force of the …

Background and Objectives The most common treatment for opioid dependence is
substitution therapy with another opioid such as methadone. The methadone dosage is …

Objective Measurement of plasma methadone concentration to investigate the rate of
clearance of methadone prescribed for heroin dependence in the first, second and third …

Background Methadone clearance is highly variable and drug interactions are problematic.
Both have been attributed to CYP3A, but actual mechanisms are unknown. Drug interactions …

Background The lack of methadone pharmacokinetic data in children and neonates
restrains dosing to achieve the target concentration in these populations. A minimum …

Methods We conducted 2 phase 1, double-blind, randomized, placebo-controlled, single-
and multiple-ascending-dose studies to investigate the safety and tolerability of oral d …