Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the
largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …

Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer
effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 …

Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people
worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to …

Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction
between inherited susceptibility alleles and environmental triggers. In the last decade …

Although the histological changes seen in psoriasis have long been well characterized, the
underlying cellular and molecular mechanisms have only begun to be elucidated over the …

Introduction Generalized pustular psoriasis (GPP) is a rare, severe, clinically heterogeneous
disease characterized by flares of widespread, noninfectious, macroscopically visible …