Health repercussions of environmental exposure to lead: Methylation perspective

SS Shiek, MS Mani, SP Kabekkodu, HS Dsouza - Toxicology, 2021 - Elsevier
Lead (Pb) exposure has been a major public health concern for a long time now due to its
permanent adverse effects on the human body. The process of lead toxicity has still not been …

Machine learning-based biomarker screening for acute myeloid leukemia prognosis and therapy from diverse cell-death patterns

Y Qin, X Pu, D Hu, M Yang - Scientific Reports, 2024 - nature.com
Acute myeloid leukemia (AML) exhibits pronounced heterogeneity and chemotherapy
resistance. Aberrant programmed cell death (PCD) implicated in AML pathogenesis …

Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity

S Bartaula-Brevik, C Leitch… - Journal of Clinical …, 2023 - mdpi.com
Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is
expressed in primary acute myeloid leukemia cells (AML), but the expression varies …

Identification and characterization of CLEC11A and its derived immune signature in gastric cancer

Q Zheng, Z Gong, B Li, R Cheng, W Luo… - Frontiers in …, 2024 - frontiersin.org
Introduction C-type lectin domain family 11 member A (CLEC11A) was characterized as a
growth factor that mainly regulates hematopoietic function and differentiation of bone cells …

CLEC11A improves insulin secretion and promotes cell proliferation in human beta-cells

R Shi, J Cen, GT Westermark, S Zhao… - Journal of …, 2023 - jme.bioscientifica.com
Beta-cell dysfunction is a hallmark of disease progression in patients with diabetes.
Research have been focused on maintaining and restoring beta-cell function during …

CLEC11A methylation is correlated to AML subtypes and cytogenetic risk factors but not patient demographics

AJ Swanson, VJ Rogowski, JA Bishop, DM Walker… - Plos one, 2024 - journals.plos.org
Acute myeloid leukemia (AML) is an aggressive and lethal cancer of the blood, which leads
to the death of over 11,000 patients in the United States each year. Research on identifying …

The causal associations of inflammatory cytokines with obesity and systemic lupus erythematosus: A Mendelian randomization study

AF Huang, L Zhou, WD Xu - International Journal of Rheumatic …, 2024 - Wiley Online Library
Objective Previous studies have partly discussed the roles of inflammatory cytokines in
obesity and systemic lupus erythematosus (SLE), but the causal relationship among …

[HTML][HTML] Characterization of ligand-receptor pair in acute myeloid leukemia: a scoring model for prognosis, therapeutic response, and T cell dysfunction

C Fu, D Qiu, M Zhou, S Ni, X Jin - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Introduction The significance of ligand-receptor (LR) pair interactions in the progression of
acute myeloid leukemia (AML) has been the focus of numerous studies. However, the …

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing data

C Liang, D Ji, F Qin, G Chen - Medicine, 2023 - journals.lww.com
The incidence rate and mortality rate of colorectal cancer (CRC) ranks third and second
globally. Cancer-associated fibroblasts (CAFs) are the major constituent of the stromal cells …

[HTML][HTML] A machine learning model identifies M3-like subtype in AML based on PML/RARα targets

T Shao, J Li, M Su, C Yang, Y Ma, C Lv, W Wang, Y Xie… - Iscience, 2024 - cell.com
The typical genomic feature of acute myeloid leukemia (AML) M3 subtype is the fusion event
of PML/RARα, and ATRA/ATO-based combination therapy is current standard treatment …