Protein–protein interactions are vital to biological processes, but the shape and size of their
interfaces make them hard to target using small molecules. Cyclic peptides have shown …

The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …

Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Abstract Urotensin II (U-II) is the most potent vasoconstrictor known, even more potent than
endothelin-1. It was first isolated from the fish spinal cord and has been recognized as a …

The cyclic peptide urotensin II (UII) was originally isolated from the urophysis of teleost fish
on the basis of its ability to contract intestinal smooth muscle. The UII peptide has …

The spine provides structure and support to the body, yet how it develops its characteristic
morphology as the organism grows is little understood. This is underscored by the …

Although urotensin II (UII) and somatostatin 1 (SS1) exhibit some structural similarities, their
precursors do not show any appreciable sequence identity and, thus, it is widely accepted …

Abstract Urotensin II (U-II), a vasoactive cyclic neuropeptide which activates the G protein-
coupled receptor UT receptor, exerts various cardiovascular effects and may play a role in …

The vasoactive peptide urotensin II (UII) is primarily expressed in motoneurons of the
brainstem and spinal cord. Intracerebroventricular injection of UII provokes various …

Biased agonism by G‐protein‐coupled receptor ligands has opened up strategies for
targeted physiological or therapeutic actions. We hypothesized that urotensin II (UII)‐derived …