Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …

Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

Inflammation is a defense process triggered when the body faces assaults from pathogens,
toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory …

Cancer is one of the leading causes of death across the world. Different environmental and
anthropogenic factors initiate mutations in different functional genes of growth factors and …

In this study, we determined the interaction of piperine and calf thymus DNA (ct DNA) in Tris-
HCl buffer solution at pH= 6.8 and also evaluated the binding mechanism through the data …

Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing
tumor incidence using synthetic or natural bioactive agents. Mechanistically …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations,
activating oncogenes, and raising oxidative stress, which all influence cell proliferation …

Piperine and piperidine are the two major alkaloids extracted from black pepper (Piper
nigrum); piperidine is a heterocyclic moiety that has the molecular formula (CH2) 5NH. Over …

Colorectal cancer (CRC) is the third most common cancer worldwide and its incidence is
expected to increase by almost 80% by 2030. CRC apparition is related to poor diet, mainly …