Anti-diabetic drugs recent approaches and advancements

J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …

[HTML][HTML] Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives

XZ Wu, WJ Zhu, L Lu, CM Hu, YY Zheng… - Arabian Journal of …, 2023 - Elsevier
In this article, a series of betulinic acid derivatives (3a∼ 3u, 4a∼ 4e) were synthesized
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …

Bioactive Diarylpentanoids: Insights into the Biological Effects beyond Antitumor Activity and Structure–Activity Relationships

J Moreira, L Saraiva, MM Pinto, H Cidade - Molecules, 2022 - mdpi.com
Diarylpentanoids, a class of natural products and their synthetic analogs which are
structurally related to chalcones, have gained increasing attention due to their wide array of …

Inhibition of α-glucosidase by flavonoids of Cymbopogon citratus (DC) Stapf

PHO Borges, S Pedreiro, SJ Baptista… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Leaves extracts from Cymbopogon citratus (DC) Stapf. are
widely used in traditional medicine exhibiting several in vivo biological activities, including …

Exploring the effect of salvianolic acid C on α-glucosidase: Inhibition kinetics, interaction mechanism and molecular modelling methods

H Tang, F Ma, D Zhao, Z Xue - Process Biochemistry, 2019 - Elsevier
Abstract α-Glucosidase has emerged as an important target for the therapy of type 2
diabetes mellitus. In our previous study, the natural product salvianolic acid C was found to …

Rapid screening of α‐glucosidase inhibitors in Hypericum perforatum L. using bio‐affinity chromatography coupled with UPLC/MS

Q Dong, N Hu, H Yue, H Wang… - Biomedical …, 2023 - Wiley Online Library
Abstract α‐glucosidase inhibitors (AGIs) are widely used for the treatment of type 2 diabetes,
but their side effects have made it to develop novel and alternative AGIs immediately. In this …

Characterization of α-Glucosidase Inhibitors from Psychotria malayana Jack Leaves Extract Using LC-MS-Based Multivariate Data Analysis and In-Silico Molecular …

TS Nipun, A Khatib, Z Ibrahim, QU Ahmed, IE Redzwan… - Molecules, 2020 - mdpi.com
Psychotria malayana Jack has traditionally been used to treat diabetes. Despite its potential,
the scientific proof in relation to this plant is still lacking. Thus, the present study aimed to …

GC-MS- and NMR-Based Metabolomics and Molecular Docking Reveal the Potential Alpha-Glucosidase Inhibitors from Psychotria malayana Jack Leaves

TS Nipun, A Khatib, Z Ibrahim, QU Ahmed… - Pharmaceuticals, 2021 - mdpi.com
Psychotria malayana Jack leaf, known in Indonesia as “daun salung”, is traditionally used for
the treatment of diabetes and other diseases. Despite its potential, the phytochemical study …

BP-M345, a new diarylpentanoid with promising antimitotic activity

P Novais, PMA Silva, J Moreira, A Palmeira, I Amorim… - Molecules, 2021 - mdpi.com
Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on
human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP …

[HTML][HTML] Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of Thiourea Derivatives Based on 3-Aminopyridin-2(1H)-Ones

Z Shulgau, I Palamarchuk, S Sergazy, A Urazbayeva… - Molecules, 2024 - mdpi.com
Reactions with allyl-, acetyl-, and phenylisothiocyanate have been studied on the basis of 3-
amino-4, 6-dimethylpyridine-2 (1 H)-one, 3-amino-4-phenylpyridine-2-one, and 3-amino-4 …