As structural genomics (SG) projects continue to deposit representative 3D structures of
proteins, homology modeling methods will play an increasing role in structure-based drug …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Hv1 voltage-gated proton channels mediate rapid and selective transmembrane H+ flux and
are gated by both voltage and pH gradients. Selective H+ transfer in membrane proteins is …

Understanding olfaction at the molecular level is challenging due to the lack of
crystallographic models of odorant receptors (ORs). To better understand the molecular …

The light-activated microbial ion channel channelrhodopsin-2 (ChR2) is a powerful tool to
study cellular processes with high spatiotemporal resolution in the emerging field of …

The mammalian olfactory system comprises a large family of G protein-coupled receptors
(GPCRs) to detect and discriminate numerous volatile ligands. More than 350 human genes …

Understanding olfaction process at a microscopic or molecular level needs more elucidation
of the multiple stages involved in the olfaction mechanism. A worth full elucidation and a …

The use of homology models in docking-based drug discovery is already established, and
provides an effective and computationally affordable alternative whenever experimental …

G-protein-coupled receptors (GPCRs) play important physiological roles related to signal
transduction and form a major group of drug targets. Prediction of GPCR–ligand complex …

With> 800 members in humans, the G protein-coupled receptor (GPCR) super-family is the
target for more than 30% of the marketed drugs. The recent boom in GPCR crystallography …