Translation elongation factor P (EF-P) is conserved in all three domains of life (called eIF5A
and aIF5A in eukaryotes and archaea, respectively) and functions to alleviate ribosome …

Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical
diversity of post-translational modifications. This results in a wide range of possibilities to …

The speed of mRNA translation depends in part on the amino acid to be incorporated into
the nascent chain. Peptide bond formation is especially slow with proline and two adjacent …

Translation of consecutive proline motifs causes ribosome stalling and requires rescue via
the action of a specific translation elongation factor, EF-P in bacteria and …

Bacteria overcome ribosome stalling by employing translation elongation factor P (EF-P),
which requires post-translational modification (PTM) for its full activity. However, EF-Ps of the …

Post-translational modifications (PTM) are the evolutionary solution to challenge and extend
the boundaries of genetically predetermined proteomic diversity. As PTMs are highly …

Thermally processed food is an important part of the human diet. Heat‐treatment, however,
promotes the formation of so‐called Amadori rearrangement products, such as …

The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella
pertussis, the causative agent of whooping cough. This toxin primarily targets innate …

Targeting translation factor proteins holds promise for developing innovative anti-
tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at …

Despite its potential importance for bacterial virulence, protein rhamnosylation has not yet
been sufficiently studied. Specific anti-SerRha, anti-ThrRha and anti-AsnRha antibodies …